valproic

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    valproic
    valparin

    it is also best known as valparin

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    valproic acid, sodium valproate, di-n-propylacetic acid, di-n-propylessigsaure, dipropylacetic acid, dpa, n-dipropylacetic acid, n-dpa, myproic acid, propylvaleric acid, sodium hydrogen divalproate, valproate semisodique, valproate semisodium, valproato semisodico, valproatum seminatricum

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    Surgery May Control Epileptic Seizures

    Brain surgery may be the most effective way to control disabling seizures in patients who suffer from a common form of epilepsy, researchers report.

    Investigators found that among patients with temporal-lobe epilepsy, 58% of surgery patients were free of disabling seizures one year later, compared with 8% of patients who took antiepileptic drugs.

    The findings lend support to the surgical treatment of temporal-lobe epilepsy, according to Dr. Samuel Wiebe of London Health Sciences Centre in London, Ontario, Canada, and colleagues. However, only about 1,500 of nearly 100,000 eligible patients in the US undergo surgery each year, the authors note in the August 2nd issue of The New England Journal of Medicine.

    To investigate, the researchers randomly assigned 40 patients to surgery and 40 patients to receive antiepileptic drugs. Scientists, who did not know which treatment the patients were receiving, assessed the frequency and severity of seizures, disability and quality of life.

    After one year, patients treated surgically had fewer severe seizures (defined as seizures during which the patient became unaware of his or her surroundings) than patients treated with drugs. Surgical patients also had a better quality of life and were slightly more likely to be employed or attending school. Rates of depression were equal among both groups.

    About 15% of surgical patients continued to have up to four disabling seizures monthly and 10% of patients had five or more seizures, the report indicates.

    "In temporal-lobe epilepsy, surgery is superior to prolonged medical therapy," Wiebe and colleagues conclude.

    Epilepsy is a brain disorder in which abnormal waves of electrical activity may lead to seizures. The patients in the current study had temporal-lobe epilepsy, which is marked by partial seizures. Partial seizures occur in only one area of the brain, and their effects can range from sudden, unexplained feelings or sensations to total loss of consciousness.

    While there is no cure for the disorder, surgery offers the only chance for patients to become free of seizures, Dr. Jerome Engel, Jr. of the University of California, Los Angeles School of Medicine, writes in an accompanying editorial.

    Still, many doctors continue to view surgery as a last resort and may continue to do so unless additional studies confirm the benefits of surgery over drugs for patients with epilepsy, he points out.



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