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    Teen smoking and nicotine dependence:
    Nicotine addiction can begin within days or weeks of smoking a first cigarette, even among occasional users, a new study indicates.

    One theory of dependence says that young people progress from the first cigarette to occasional use and then to increasingly heavy daily use before becoming dependent, according to the researchers. That theory was developed from studies of adult smokers who did not become dependent, despite smoking up to five cigarettes daily for years.

    Team followed 681 adolescents, ages 11 to 15, who attended central Massachusetts schools during 1998 as part of the Development and Assessment of Nicotine Dependence in Youth study. Students were interviewed about their tobacco use and symptoms of dependency three times during the year.

    Ninety-five students were classified as monthly smokers - those who had smoked at least two cigarettes within a 2-month period. About 20 percent of those students reported symptoms of dependency within 4 weeks of starting to smoke, and 16 developed symptoms within 2 weeks, the researchers say.

    Nearly two-thirds (60) of the monthly smokers said they had experienced one or more symptoms of nicotine dependence. The most common initial symptom was a feeling of being addicted, the researchers say. Strong urges to smoke, and feeling irritable, nervous, restless or anxious when unable to do so were the most commonly reported symptoms overall.

    Thirty-seven of the adolescents said they felt their first symptom before they began daily smoking, or they began smoking every day upon experiencing their first symptom.

    The authors propose that people be placed into three groups according to susceptibility to nicotine dependence: rapid onset, slower onset and resistant.

    They cited animal studies showing that the number of nicotine receptors in the brain increased rapidly after the second dose of nicotine, possibly explaining development of dependence.

    The study is published in the autumn issue of the journal Tobacco Control.



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