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    Symptoms of depression and anxiety are common in patients with epilepsy; some researchers estimate that up to 75 percent experience some symptoms of depression. Several studies have reported that one of the newer anti-seizure drugs, gabapentin, seems to be effective in treating mood disorders. A recent study looked at the drug's effects on depression specifically in patients with partial epilepsy.

    Researchers from Weill Medical College of Cornell University in New York City compared two groups of 20 adult patients with partial epilepsy. One group had gabapentin added to their anti-epileptic drug regimen, and the other group did not change their regimen. Gabapentin was added to help control seizures, but the researchers also measured symptoms of depression and anxiety at the beginning and end of the study.

    For each patient, the study lasted for two weeks after a dose of gabapentin sufficient for seizure control was reached. This varied from one to six months, with an average of three. The control group patients were evaluated at about three months.

    Interestingly, there were no statistically significant differences between the baseline frequency of seizures and the number experienced at study's end for either group, though the gabapentin group did have more patients who reported a decrease.

    What did differ significantly between groups was scores on the Cornell Dysthymia Rating Scale, a measure of mood disturbance. Patients taking gabapentin showed significant reductions in their scores on this test, indicating improved mood. Of the 12 patients with scores in the upper range to start with, six scored in the lower range after taking gabapentin. In the control group, only one patient showed this level of improvement.

    Also of interest is that the amount of gabapentin taken had no significant relationship to patients' mood scores.

    This study was limited in that it was small, there was no placebo group, and patients chose whether or not to add gabapentin to their epilepsy regimen. However, the results of this study back up other reports that gabapentin appears effective in improving symptoms of depression and other mood disturbances.

    The authors, writing in the journal "Epilepsia," call for more research into treating depression in patients with epilepsy.


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