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    Study: New Test for Colon Cancer More Accurate, Convenient

    A new test for detecting colorectal cancer appears to be more accurate than the traditional test used to measure blood in the stool, according to Canadian researchers at St. Michaels' Hospital in Toronto, Ontario.

    The new test, called ColorectAlert, detects the presence of a carbohydrate found in intestinal mucus. The scientists who discovered this test believe that it may be a more specific indicator of cancer than the old test, which detects the presence of blood in the stool. Blood can be a sign of cancer, but it also can indicate other problems.

    The results of the study were presented at the Digestive Disease Week conference in San Diego, a gathering of worldwide gastrointestinal experts.

    "ColorectAlert has the ability to detect colorectal cancer at a stage when a patient is still symptom free," explained Dr. Norman Marcon, lead investigator for the study. "Using it could reduce the cost of screening programs - for example, reduce the number of colonoscopies."

    To use ColorectAlert, the doctor takes a sample of mucus during a digital exam of the rectum and places the specimen on special paper. A handheld machine reads the color, which indicates the presence or absence of the carbohydrate.

    About 670 volunteers participated in the study. Each submitted three stool samples for occult blood testing, and underwent the ColorectAlert test. The former identified 75 percent of the cancers that were confirmed by colonoscopy; the latter identified 80 percent of the cancers that were identified by colonoscopy.

    The developers of ColorectAlert, International Medical Innovations Inc. of Toronto, hope the new test will replace the occult blood test, which requires three consecutive stool samples and refraining from certain foods, including red meat, for a week. ColorectAlert is done by the doctor during one examination and requires no food restrictions.

    "The data from the study is very comprehensive," Marcon said, "and our initial analysis supports the previously published scientific studies showing that ColorectAlert can identify individuals at risk for having early stage colorectal cancer."

    Colorectal cancer ranks as the third most prevalent cancer in North America and the second most common cause of death due to cancer. About 148,000 new cases are diagnosed in North America annually (16,500 in Canada). If caught early, nine in 10 cases of colorectal cancer can be cured. If it spreads beyond the intestinal wall, however, it is generally fatal within five years.

    Colorectal cancer is categorized into four groups:

    Stage A: tumor is limited to the wall of the colon or rectum

    Stage B: tumor has extended to tissue outside the colon

    Stage C: tumor has spread to regional lymph nodes

    Stage D: tumor has spread to distant organs



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