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    Researchers from the University at Buffalo in New York have discovered another function for melatonin: Helping to form bone tissue.

    Using cells from mice and rats, researchers exposed two types of cells, pre-osteoblasts and osteoblasts to melatonin. Osteoblasts are the cells within bones that produce substances that are used as a framework (matrix) for bone tissue. They also mineralize these substances, which is what makes bones hard. Pre-osteoblasts are cells that will develop into functioning osteoblasts in about 21 days.

    When exposed to melatonin at approximately the same level found naturally in the body, the pre-osteoblasts develop into osteoblasts in only 12 days and both types of cells begin producing the proteins that help make up the bone matrix. The osteoblasts that were mature prior to the exposure to melatonin react to its presence in less than one hour. The newly formed osteoblasts require five to seven days before they respond.

    Researchers are hoping to use this discovery to explore whether melatonin may help prevent osteoporosis, a weakening and loss of bone tissue that usually occurs with aging. Interestingly, natural melatonin production also decreases with age.

    Up to this point, melatonin, which is a hormone produced by the tiny pineal gland located in the brain, has been under investigation for the role it plays in the natural sleep-wake cycle. Melatonin is produced when your eyes perceive darkness, and it mildly induces sleep by signaling your brain that it is night. Melatonin has been used recently as a treatment for jet lag and other disturbances of normal sleep patterns.

    Optimism prevails among the researchers who believe that the timing of melatonin decreasing with age and osteoporosis increasing with age may not be just a coincidence. They hope that with further study, melatonin may develop into a potential treatment or prevention therapy for osteoporosis.



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