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    Multiple myeloma and thalidomide:
    Thalidomide, a drug pulled from the market in the early 1960s after it was found to cause severe birth defects, can be an effective treatment for multiple myeloma, an often fatal cancer, researchers say.

    A study by researchers at Mayo Clinic Cancer Center, Rochester, Minn., found that 25 percent of study participants with advanced multiple myeloma responded to thalidomide therapy after failing conventional medical treatments.

    There is no cure for multiple myeloma, an often fatal cancer that develops in the bone marrow. Standard medical treatments include chemotherapy, radiation therapy and bone marrow transplantation. People diagnosed with the cancer live an average of 4 years with treatment.

    Those in the study were given 200 milligrams of thalidomide daily for 2 weeks. The dosage was increased to a maximum daily dose of 800 mg.

    Thalidomide was used in some countries in the mid-1950s as a sleeping pill. The drug was subsequently found to effectively control morning sickness during pregnancy. Unfortunately, it was not realized that the drug also could cause severe malformations of the arms, legs and some organs in an unborn child. Thalidomide was taken off the market worldwide in 1962.

    In recent years, researchers began studying thalidomide again and found the drug could potentially decrease the blood supply to some cancers.



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