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    Researchers at the University of Buffalo and Roswell Cancer Center have announced evidence that a defect in the gene that regulates your triglyceride level may increase your risk for breast cancer.

    The gene, known as apoE, is involved in maintaining normal triglyceride and cholesterol levels in your blood by controlling fat metabolism. ApoE4, a variation of this gene, has been associated with high levels of cholesterol and triglycerides, and a higher risk for heart disease and Alzheimer's disease.

    But what is the relationship between triglycerides and breast cancer? Blood samples from 256 women with breast cancer and 325 women without it were tested for triglyceride levels and to see what variation of the apoE gene they carried. The apoE4 version was found in 24 percent of the total number of participants.

    Having a high triglyceride level in itself, increases a woman's risk for breast cancer. In comparison studies, breast cancer risk was increased by 70 percent in women with the highest levels of triglycerides, when compared to women with the lowest triglyceride levels.

    When just the gene variations were compared, women with apoE4 showed no higher risk of breast cancer than women with other versions of the apoE gene (there's apoE, apoE2, and apoE3).

    However, when all the factors were analyzed together, high triglyceride levels were only associated with a higher risk of breast cancer if the woman had the apoE4 gene type.

    Researchers are excited about this new discovery, but caution that further studies are needed to reproduce these findings before any conclusions can be made. Should additional studies have the same results, medicine may be a little closer to understanding how genes and diet contribute to your risk for breast cancer.



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