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    Study: Zinc Nasal Spray Has No Significant Effect on Cold Symptoms

    Viral upper respiratory infections-the common cold-are common and sometimes debilitating illnesses, with an average duration of about a week. Since adults may expect to suffer 2 or 3 such infections each year, a remedy with significant benefits on intensity or duration of cold symptoms would be welcome.

    Zinc, in various forms, has been promoted as a possible treatment for colds, moreso in recent years Recently, studies have shown conflicting results for the efficacy of zinc lozenges in cold treatment. A new study appearing in the August 3rd issue of the American Journal of Medicine does not support any role for a zinc nasal spray as a benefit for those suffering from colds.

    Edward Belongia, MD, Richard Berg, MS, and Kejian Liu, PhD, of the Marshfield Clinic in Marshfield Wisconsin, studied 160 volunteers study of the effects of a zinc nasal spray on 8 cold symptoms over a 14 day period. Study patients were required to be non-smokers and not taking antibiotics, and had to enter the study within 24 hours of the onset of cold symptoms. Screening tests for Streptococcal infection, pregnancy, and specific viral infections were done; presence of Strep or pregnancy rendered the patient ineligible for the study.

    All patients received nasal spray bottles which were identical, except that the active group got a solution with 0.12% zinc in sterile water and salt solution, while the inactive placebo group s spray had no zinc. Neither the participants nor the evaluating scientists knew which patients had active spray. Participants were supposed to spray twice into each nostril, four times daily.

    Each participant filled out a symptom diary detailing the presence or absence of 8 cold symptoms: stuffy or runny nose, hoarseness, sore/itchy throat, cough, headache, sneezing, or muscle ache. Patients were phoned on days 2 and 6 of the study to encourage compliance, answer questions, and monitor for adverse reactions.

    The primary outcome measure was symptom score, defined as the sum of the 8 symptom scores during each morning and evening diary record. The investigators concluded, after the medication code was revealed and the nature of each participants' spray was analyzed, that the zinc spray had no significant effect on cold symptom duration or intensity. There were no differences in the minor adverse events.

    The authors point out that "there is great interest in alternative medicine in the United States, and homeopathic remedies for the common cold are widely marketed. These include echinacea, zinc lozenges, and most recently a zinc nasal spray." But, they conclude, "a nasal spray of 0.12% zinc sulfate has no effect on the duration of the common cold."



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