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    cyclophosphamide
    cytoxan

    it is also best known as cytoxan

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    cytophosphane

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    Anticancer Supplements

    According to the World Health Organization cancer incidents around the world continue to rise. New cancer cases are expected to reach 20 million annually by the year 2020. While medical professions strive to improve diagnosis and treatment strategies, public health efforts are directed toward prevention. Many people are taking their own steps. It is estimated that a conservative one-third of the U.S. Population is already using dietary supplements for one reason or another. Cancer prevention is certainly one motivator for this trend.

    While knowledge and experience with dietary supplementation is still in its infancy, scientific evidence for the power of good nutrition to prevent cancer is growing. According to experts, the future holds potential to match nutritional strategy with specific cancer prevention. For now, however, important questions are being asked and work is underway to find unbiased answers. There is a very real concern that too much of anything, including natural products thought to be protective, can result in "overnutrition" health problems, including cancer.

    A Growing Concern

    For those with cancer, there is growing concern that pharmacological use of antioxidant vitamin, mineral and herbals might interfere with anticancer therapies such as chemotherapy. Pharmacological use is when a vitamin, mineral, or herbal is used in excess of basic daily needs. Many chemotherapy drugs work by creating free radical species of oxygen to produce an anti-tumor effect. When there are high circulating levels of antioxidants, it is proposed that this may interrupt the reactive oxygen effect early, resulting in a reduction of the chemotherapy dose. Not all chemotherapy drugs utilize the reactive oxygen pathway. The chemotherapy drugs that may be affected by antioxidants include alkylating agents (busulfan, cytoxan), anthracyclines (doxorubicin, daunorubicin), mitomycin, bleomycin, and etopiside. If you are using high dose antioxidants and undergoing chemotherapy, notify your oncologist so they may appropriately manage your anticancer therapy.

    A Basic Fact

    The most important nutritional fact well-supported by research is that a predominantly plant-based diet, rich in vegetables, fruit, whole grains and beans is your best protection. Of the 202 studies on the association between vegetables and fruit and cancer examined by an AICR (American Institute for Cancer Research) panel, an astounding 78 percent show those foods to be cancer-preventive. Mother was right, "Eat your fruits and vegetables". In the meantime, the research goes on. Here is a summary of some foods and nutritional factors being studied.

    Soy What's New?

    Genistein, a phytoestrogen found in soy, may help prevent breast cancer. The incidence of prostate and breast cancers is lower in Asians, and typically soy is an important food in Asian diets. Recent research adds information about the mechanisms of this observation.

    One study found soy to protect against chemically induced mammary cancers in pre-pubertal rats. Other studies have found that soy's phytoestrogen competes with natural estrogen on cells. The result? Lower levels of the naturally occurring hormone, increased antioxidant power to prevent formation of free radicals and DNA damage and, possibly, lower cancer risk. For those already fighting breast cancer, the early research is not as good. Soy may actually help the bad cancer cells grow more. Again, more research is needed in this important area.

    Green Tea, Anyone?

    The key ingredient in green tea is called epigallocatechin gallate (EGCG). This chemical is the most powerful of the main tea polyphenols called "catechins". It made headlines as a potent warrior against carcinogenesis, neutralizer of free radicals and blocker of cell mutations. Rectal and pancreatic cancer prevention were specifically noted. Tea all day long sounds like a bit much for many of us. Up to twelve cups per day contains the amount of EGCG being studied. But, a little green tea is certainly a tasty way to get a little EGCG.

    Selenium For The New Millennium?

    Several forms of this soil-based mineral demonstrate the ability to kill cancer cells and prevent its growth. Specifically, methylselenol, a recently researched form of selenium, was the most powerful to prevent growth of blood vessels that feed tumors. This nutrient is showing some early promise in the areas of lung, colorectal, and prostate cancers. While it naturally occurs in whole grains, seafood, garlic, eggs, and mushrooms, at least one-third of Americans don't consume the recommended 70 mcg. for men and 55 mcg. For women. The trick here is to get "enough", and foods can be a great source. Excessive selenium supplementation is very toxic.

    Jaws Rides Again?

    Shark Cartilage! Not filet of shark, but the cartilage of shark, is being studied. The National Cancer Institute has Phase 2 and 3 studies underway to evaluate the benefit of supplementing up to 2 grams of shark cartilage per kilogram of body weight. The question being studied is, "Can this product help reduce angiogenesis (blood vessel formation to feed tumors)?" Some studies suggested positive results using high dosages for faster growing tumors in advanced stages of cancer (breast, prostate, and brain). How much is enough to supplement and does it actually prevent cancer? Stay tuned. This is another area where complete information is not yet available.

    Vitamin E

    Evidence continues to build with regard to Vitamin E in health protection. In a recent study of almost 30,000 male smokers aged 50-69 in Finland, scientists found that a 50 mg daily dose of 'synthetic' vitamin E for five to eight years decreased prostate cancer incidence by over 30 percent. They also found supplements decreased deaths from prostate cancer by 41 percent. Interestingly, that same sample of men who were simultaneously taking beta-carotene as a supplement (not food sources) showed an increase incidence in prostate cancer, and mortality!

    Vitamin E, like other antioxidants, neutralizes free radicals that can initiate or promote tumor development. Natural vitamin E is more potent then synthetic varieties and thought by some to be a superior choice as a supplement. How much is recommended? Some experts in heart health suggest 200-400 IU per day. For cancer prevention, the numbers are still a bit fuzzy.


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