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    Seizures

    Lamotrigine, an anti-seizure medication approved for treating adults with partial seizures, may also be helpful for children, according to a new study reported recently in the journal "Neurology."

    A multicenter team of researchers from four universities in France and the United States studied 201 children with partial seizures, ages two to 12. All the children were already taking medication for their epilepsy, but still had eight or more partial seizures over the eight-week baseline period before the study began.

    Seizures are abnormal electrical discharges in the brain that temporarily disrupt brain function. Partial seizures affect only one area of the brain, but they can spread to the entire brain, a process called secondary generalization.

    For 18 weeks, the children in the study continued to take their epilepsy medications and took either lamotrigine or a placebo in addition. A total of 167 children completed the study, with similar numbers dropping out from the treatment and placebo groups.

    Among children taking lamotrigine, 42 percent had at least a 50 percent reduction in partial seizures during the study; only 18 percent of the placebo patients had this much improvement. Similar reductions were seen for partial seizures with secondary generalization.

    Side-effects were mostly mild to moderate in both the treatment and placebo groups, but the treatment group reported more impaired coordination, dizziness, tremor, and nausea. Rash, which is a noted side-effect of lamotrigine, was reported in 16 children in the treatment group and 18 in the placebo group.

    "There is a tremendous need for medications such as lamotrigine that are proven safe for children," stated lead study author Michael Duchowny of Miami Children's Hospital in Florida. "Parents don't want to put their children at risk by giving them medications that may cause serious side effects." Some anti-epileptic drugs can cause damage to the brain, liver, gastrointestinal system, and blood.

    Co-author William Graf of the Children's Hospital and Regional Medical Center in Seattle, Washington, agreed. "At last children with hard-to-control epilepsy can enjoy more seizure-free days," he commented, noting that lamotrigine does not cause drowsiness. "Kids can now stay awake in class and participate in after-school activities. That's exciting news."


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